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Mirogabalin, the active ingredient in Sindola, belongs to the class of gamma amino acids and their derivatives. It works by selectively binding to the α2δ subunits of voltage-gated calcium channels (VGCCs), reducing calcium influx and neurotransmitter release in presynaptic neurons. This results in decreased hyper-excitability of neurons in the central nervous system (CNS).
Absorption and Distribution:
- Mirogabalin is rapidly absorbed, with a median time to peak plasma concentration of 0.5 to 1.5 hours.
- It has low plasma protein binding (~25%) and a volume of distribution ranging from 64-88L after single or repeated doses.
Metabolism and Excretion:
- Most of the drug (61-72%) is excreted unchanged through the kidneys, with a smaller portion (13-20%) metabolized by liver enzymes (specifically uridine 5'-diphosphate-glucuronosyltransferase isoforms).
- The elimination half-life is approximately 2-4.9 hours, with 99% excretion via the kidneys and only 1% through feces.
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✅ Description:
Sindola tablet is prescribed for the treatment of the following conditions:
- Neuropathic pain
- Diabetic peripheral neuropathic pain (DPNP)
- Postherpetic neuralgia (PHN)
- Peripheral neuropathic pain (PNP)
Take this medication only as directed by a registered physician.
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✔️ Side Effects of Sindola 5
The most commonly reported side effects include:
- Somnolence
- Dizziness
- Edema
- Weight gain
Rare symptoms that require immediate medical attention:
- Dizziness, sleepiness, or loss of consciousness.
- General weakness, loss of appetite, nausea, vomiting, or jaundice (indicating potential liver dysfunction).
✔️ How does Sindola 5 work?
Mirogabalin exhibits selective and potent binding affinities for the human α2δ subunits of voltage-gated calcium channels (VGCCs). This action reduces calcium (Ca²⁺) influx and neurotransmission in the dorsal root ganglia (DRG). By inhibiting calcium entry, Mirogabalin decreases the release of neurotransmitters at the presynaptic neuron endings, thereby reducing neuronal excitability and alleviating pain signals.
✔️ Dosage & Administration of Sindola 5
- Adults:
- Start with 5 mg twice daily, gradually increasing by 5 mg every week to a maximum of 15 mg twice daily, depending on the patient’s age and symptoms.
- Children and Adolescents:
- The safety and effectiveness of children and adolescents have not been established.
- Hepatic Impairment:
- A single 15 mg dose is generally safe for patients with mild to moderate liver impairment. No data is available for severe impairment.
- Renal Impairment:
- Mild renal dysfunction: Start at 5 mg twice daily, increasing weekly by 5 mg to a maximum of 10 mg twice daily.
- Moderate renal dysfunction: Start at 2.5 mg twice daily, increasing weekly by 2.5 mg to a maximum of 7.5 mg twice daily.
- Severe renal dysfunction: Start at 2.5 mg once daily, increasing weekly by 2.5 mg to a maximum of 7.5 mg once daily.
Always follow your doctor's advice when taking this medication.
✔️ Drug Interactions
With other medications:
- Co-administration with Cimetidine or Probenecid may increase Mirogabalin plasma levels.
- When combined with Lorazepam, it may enhance central nervous system (CNS) depressive effects.
- Mirogabalin is a substrate for OAT1, OAT3, OCT2, MATE1, MATE2-K, and UGT enzymes. Use caution when administering inhibitors of these pathways.
With food and alcohol:
- Food has no significant impact on the absorption of Mirogabalin.
- Avoid alcohol consumption, as it can enhance sedation and impair motor skills.
✔️ Contraindications
- Hypersensitivity to Mirogabalin.
- Patients with mild to moderate hepatic or renal impairment.
✔️ Pregnancy & Lactation
- Use during pregnancy only if the potential benefits outweigh the risks, as animal studies suggest placental transfer of the drug.
- For breastfeeding, carefully consider whether to discontinue breastfeeding or the medication, as animal studies indicate the drug can be transferred into breast milk.
✔️ Precautions & Warnings
- This medication can cause dizziness, drowsiness, or loss of consciousness; avoid operating machinery or driving.
- It may lead to weight gain and vision problems (blurred or double vision).
- Elderly patients should be cautious due to an increased risk of falls or fractures.
- If allergic reactions occur, discontinue use and consult a doctor.
- Dose adjustments may be required for patients with renal dysfunction.
✔️ Storage Conditions
- Store below 30°C in a dry, cool place, away from light and moisture.
- Keep out of reach of children.
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here information is for informational purposes only.
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lab tests, medicines, all possible side effects, drug interactions,
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